| Girone Unico |
| 16/09/202518:45 | PSV EindhovenVan Bommel R. | 1 - 3 | Union Saint GilloiseDavid P. (rigore), Ait El Hadj A., Mac Allister K. |
| 16/09/202518:45 | Athletic Bilbao | 0 - 2 | ArsenalMartinelli G., Trossard L. |
| 16/09/202521:00 | JuventusYildiz K., Vlahovic D., Vlahovic D., Kelly L. | 4 - 4 | Borussia DortmundAdeyemi K., Nmecha F., Couto Y., Bensebaini R. (rigore) |
| 16/09/202521:00 | TottenhamJunior L. (autogoal) | 1 - 0 | Villarreal |
| 16/09/202521:00 | BenficaBarrenechea E., Pavlidis V. | 2 - 3 | QarabagAndrade L., Duran C., Kashchuk O. |
| 16/09/202521:00 | Real MadridMbappè K. (rigore), Mbappè K. (rigore) | 2 - 1 | Olympique MarsigliaWeah T. |
| 17/09/202518:45 | Slavia PragaMbodji Y., Mbodji Y. | 2 - 2 | Bodo GlimtBassi D., Fet S. |
| 17/09/202518:45 | Olympiacos | 0 - 0 | Pafos |
| 17/09/202521:00 | Bayern MonacoChalobah T. (autogoal), Kane H. (rigore), Kane H. | 3 - 1 | ChelseaPalmer C. |
| 17/09/202521:00 | Ajax | 0 - 2 | InterThuram M., Thuram M. |
| 17/09/202521:00 | Paris Saint-GermainMarquinhos M., Kvaratskhelia K., Mendes N., Ramos G. | 4 - 0 | Atalanta |
| 17/09/202521:00 | LiverpoolRobertson A., Salah M., Van Dijk V. | 3 - 2 | Atletico MadridLlorente M., Llorente M. |
| 18/09/202518:45 | CopenaghenLarsson J., Robert V. | 2 - 2 | Bayer LeverkusenGrimaldo A., Hatzidiakos P. (autogoal) |
| 18/09/202518:45 | Club BrugesTresoldi N., Onyedika R., Vanaken H., Diakhon M. | 4 - 1 | Monaco ASFati A. |
| 18/09/202521:00 | NewcastleGordon A. | 1 - 2 | BarcellonaRashford M., Rashford M. |
| 18/09/202521:00Matteo La Bella | Manchester CityHaaland E., Doku J. | 2 - 0 | Napoli |
| 18/09/202521:00 | Eintracht FrancoforteSanchez D. (autogoal), Uzun C., Singo W. (autogoal), Burkardt J., Knauff A. | 5 - 1 | GalatasarayAkgun Y. |
| 18/09/202521:00 | Sporting LisbonaTrincão F., Trincão F., Santos A., Quenda G. | 4 - 1 | Kairat AlmatyEdmilson D. |
| 30/09/202518:45 | Kairat Almaty | 0 - 5 | Real MadridMbappè K. (rigore), Mbappè K., Mbappè K., Camavinga E., Diaz B. |
| 30/09/202518:45 | AtalantaSamardzic L. (rigore), Pasalic M. | 2 - 1 | Club BrugesTzolis C. |
| 30/09/202521:00 | Atletico MadridRaspadori G., Le Normand R., Griezmann A., Simeone G., Alvarez J. (rigore) | 5 - 1 | Eintracht FrancoforteBurkardt J. |
| 30/09/202521:00 | Bodo GlimtHauge J., Hauge J. | 2 - 2 | TottenhamVan De Ven M., Gundersen J. (autogoal) |
| 30/09/202521:00 | PafosOrsic M. | 1 - 5 | Bayern MonacoKane H., Guerreiro R., Jackson N., Kane H., Olise M. |
| 30/09/202521:00 | InterLautaro Martinez J., Dumfries D., Lautaro Martinez J. | 3 - 0 | Slavia Praga |
| 30/09/202521:00 | Olympique MarsigliaPaixão I., Paixão I., Greenwood M., Aubameyang P. | 4 - 0 | Ajax |
| 30/09/202521:00 | ChelseaRios R. (autogoal) | 1 - 0 | Benfica |
| 30/09/202521:00 | GalatasarayOsimhen V. (rigore) | 1 - 0 | Liverpool |
| 01/10/202518:45 | QarabagZoubir A., Addai E. | 2 - 0 | Copenaghen |
| 01/10/202518:45 | Union Saint Gilloise | 0 - 4 | NewcastleWoltemade N., Gordon A. (rigore), Gordon A. (rigore), Barnes H. |
| 01/10/202521:00 | NapoliHojlund R., Hojlund R. | 2 - 1 | Sporting LisbonaSuarez L. (rigore) |
| 01/10/202521:00 | Monaco ASTeze J., Dier E. (rigore) | 2 - 2 | Manchester CityHaaland E., Haaland E. |
| 01/10/202521:00 | BarcellonaTorres F. | 1 - 2 | Paris Saint-GermainMayulu S., Ramos G. |
| 01/10/202521:00 | ArsenalMartinelli G., Saka B. | 2 - 0 | Olympiacos |
| 01/10/202521:00 | Borussia DortmundSvensson D., Chukwuemeka C., Guirassy S., Brandt J. | 4 - 1 | Athletic BilbaoGuruzeta G. |
| 01/10/202521:00 | VillarrealMikautadze G., Veiga R. | 2 - 2 | JuventusGatti F., Conceicao F. |
| 01/10/202521:00 | Bayer LeverkusenKofane C. | 1 - 1 | PSV EindhovenSaibari I. |
| 21/10/202518:45 | Kairat Almaty | 0 - 0 | Pafos |
| 21/10/202518:45 | Barcellona | 6 - 1 | Olympiacos |
| 21/10/202521:00 | Newcastle | 3 - 0 | Benfica |
| 21/10/202521:00 | Villarreal | 0 - 2 | Manchester City |
| 21/10/202521:00 | Copenaghen | 2 - 4 | Borussia Dortmund |
| 21/10/202521:00 | Union Saint Gilloise | 0 - 4 | Inter |
| 21/10/202521:00 | Bayer Leverkusen | 2 - 7 | Paris Saint-Germain |
| 21/10/202521:00 | PSV Eindhoven | 6 - 2 | Napoli |
| 21/10/202521:00 | Arsenal | 4 - 0 | Atletico Madrid |
| 22/10/202518:45 | Athletic Bilbao | 3 - 1 | Qarabag |
| 22/10/202518:45 | Galatasaray | 3 - 1 | Bodo Glimt |
| 22/10/202521:00 | Real Madrid | 1 - 0 | Juventus |
| 22/10/202521:00 | Atalanta | 0 - 0 | Slavia Praga |
| 22/10/202521:00 | Bayern Monaco | 4 - 0 | Club Bruges |
| 22/10/202521:00 | Monaco AS | 0 - 0 | Tottenham |
| 22/10/202521:00 | Eintracht Francoforte | 1 - 5 | Liverpool |
| 22/10/202521:00 | Sporting Lisbona | 2 - 1 | Olympique Marsiglia |
| 22/10/202521:00 | Chelsea | 5 - 1 | Ajax |
| 04/11/202518:45 | Napoli | 0 - 0 | Eintracht Francoforte |
| 04/11/202518:45 | Slavia Praga | 0 - 3 | Arsenal |
| 04/11/202521:00 | Liverpool | 1 - 0 | Real Madrid |
| 04/11/202521:00 | Tottenham | 4 - 0 | Copenaghen |
| 04/11/202521:00 | Juventus | 1 - 1 | Sporting Lisbona |
| 04/11/202521:00 | Paris Saint-Germain | 1 - 2 | Bayern Monaco |
| 04/11/202521:00 | Bodo Glimt | 0 - 1 | Monaco AS |
| 04/11/202521:00 | Olympiacos | 1 - 1 | PSV Eindhoven |
| 04/11/202521:00 | Atletico Madrid | 3 - 1 | Union Saint Gilloise |
| 05/11/202518:45 | Qarabag | 2 - 2 | Chelsea |
| 05/11/202518:45 | Pafos | 1 - 0 | Villarreal |
| 05/11/202521:00 | Club Bruges | 3 - 3 | Barcellona |
| 05/11/202521:00 | Newcastle | 2 - 0 | Athletic Bilbao |
| 05/11/202521:00 | Ajax | 0 - 3 | Galatasaray |
| 05/11/202521:00 | Manchester City | 4 - 1 | Borussia Dortmund |
| 05/11/202521:00 | Benfica | 0 - 1 | Bayer Leverkusen |
| 05/11/202521:00 | Inter | 2 - 1 | Kairat Almaty |
| 05/11/202521:00 | Olympique Marsiglia | 0 - 1 | Atalanta |
| 25/11/202518:45 | Galatasaray | 0 - 1 | Union Saint Gilloise |
| 25/11/202518:45 | Ajax | 0 - 2 | Benfica |
| 25/11/202521:00 | Manchester City | 0 - 2 | Bayer Leverkusen |
| 25/11/202521:00 | Napoli | 2 - 0 | Qarabag |
| 25/11/202521:00Giulio Cardone | Bodo Glimt | 2 - 3 | Juventus |
| 25/11/202521:00 | Slavia Praga | 0 - 0 | Athletic Bilbao |
| 25/11/202521:00 | Chelsea | 3 - 0 | Barcellona |
| 25/11/202521:00 | Olympique Marsiglia | 2 - 1 | Newcastle |
| 25/11/202521:00 | Borussia Dortmund | 4 - 0 | Villarreal |
| 26/11/202518:45 | Pafos | 2 - 2 | Monaco AS |
| 26/11/202518:45 | Copenaghen | 3 - 2 | Kairat Almaty |
| 26/11/202521:00 | Atletico Madrid | 2 - 1 | Inter |
| 26/11/202521:00 | Olympiacos | 3 - 4 | Real Madrid |
| 26/11/202521:00 | Arsenal | 3 - 1 | Bayern Monaco |
| 26/11/202521:00 | Liverpool | 1 - 4 | PSV Eindhoven |
| 26/11/202521:00 | Sporting Lisbona | 3 - 0 | Club Bruges |
| 26/11/202521:00 | Eintracht Francoforte | 0 - 3 | Atalanta |
| 26/11/202521:00 | Paris Saint-Germain | 5 - 3 | Tottenham |
| 09/12/202516:30 | Kairat Almaty | 0 - 1 | Olympiacos |
| 09/12/202518:45 | Bayern Monaco | 3 - 1 | Sporting Lisbona |
| 09/12/202521:00 | Tottenham | 3 - 0 | Slavia Praga |
| 09/12/202521:00 | Barcellona | 2 - 1 | Eintracht Francoforte |
| 09/12/202521:00 | Union Saint Gilloise | 2 - 3 | Olympique Marsiglia |
| 09/12/202521:00 | Atalanta | 2 - 1 | Chelsea |
| 09/12/202521:00 | PSV Eindhoven | 2 - 3 | Atletico Madrid |
| 09/12/202521:00 | Monaco AS | 1 - 0 | Galatasaray |
| 09/12/202521:00 | Inter | 0 - 1 | Liverpool |
| 10/12/202518:45 | Villarreal | 2 - 3 | Copenaghen |
| 10/12/202518:45 | Qarabag | 2 - 4 | Ajax |
| 10/12/202521:00 | Juventus | 2 - 0 | Pafos |
| 10/12/202521:00 | Athletic Bilbao | 0 - 0 | Paris Saint-Germain |
| 10/12/202521:00 | Club Bruges | 0 - 3 | Arsenal |
| 10/12/202521:00 | Benfica | 2 - 0 | Napoli |
| 10/12/202521:00 | Borussia Dortmund | 2 - 2 | Bodo Glimt |
| 10/12/202521:00 | Real Madrid | 1 - 2 | Manchester City |
| 10/12/202521:00 | Bayer Leverkusen | 2 - 2 | Newcastle |
| 20/01/202616:30 | Kairat Almaty | 1 - 4 | Club Bruges |
| 20/01/202618:45 | Bodo Glimt | 3 - 1 | Manchester City |
| 20/01/202621:00 | Villarreal | 1 - 2 | Ajax |
| 20/01/202621:00 | Olympiacos | 2 - 0 | Bayer Leverkusen |
| 20/01/202621:00 | Tottenham | 2 - 0 | Borussia Dortmund |
| 20/01/202621:00 | Inter | 1 - 3 | Arsenal |
| 20/01/202621:00 | Sporting Lisbona | 2 - 1 | Paris Saint-Germain |
| 20/01/202621:00 | Copenaghen | 1 - 1 | Napoli |
| 20/01/202621:00 | Real Madrid | 6 - 1 | Monaco AS |
| 21/01/202618:45 | Qarabag | 3 - 2 | Eintracht Francoforte |
| 21/01/202618:45 | Galatasaray | 1 - 1 | Atletico Madrid |
| 21/01/202621:00 | Newcastle | 3 - 0 | PSV Eindhoven |
| 21/01/202621:00 | Atalanta | 2 - 3 | Athletic Bilbao |
| 21/01/202621:00 | Juventus | 2 - 0 | Benfica |
| 21/01/202621:00 | Slavia Praga | 2 - 4 | Barcellona |
| 21/01/202621:00 | Bayern Monaco | 2 - 0 | Union Saint Gilloise |
| 21/01/202621:00 | Olympique Marsiglia | 0 - 3 | Liverpool |
| 21/01/202621:00 | Chelsea | 1 - 0 | Pafos |
| 28/01/202621:00 | Union Saint Gilloise | 1 - 0 | Atalanta |
| 28/01/202621:00 | Atletico Madrid | 1 - 2 | Bodo Glimt |
| 28/01/202621:00 | Manchester City | 2 - 0 | Galatasaray |
| 28/01/202621:00 | Ajax | 1 - 2 | Olympiacos |
| 28/01/202621:00 | Club Bruges | 3 - 0 | Olympique Marsiglia |
| 28/01/202621:00 | PSV Eindhoven | 1 - 2 | Bayern Monaco |
| 28/01/202621:00 | Athletic Bilbao | 2 - 3 | Sporting Lisbona |
| 28/01/202621:00 | Liverpool | 6 - 0 | Qarabag |
| 28/01/202621:00 | Napoli | 2 - 3 | Chelsea |
| 28/01/202621:00 | Borussia Dortmund | 0 - 2 | Inter |
| 28/01/202621:00 | Paris Saint-Germain | 1 - 1 | Newcastle |
| 28/01/202621:00 | Monaco AS | 0 - 0 | Juventus |
| 28/01/202621:00 | Barcellona | 4 - 1 | Copenaghen |
| 28/01/202621:00 | Benfica | 4 - 2 | Real Madrid |
| 28/01/202621:00 | Bayer Leverkusen | 3 - 0 | Villarreal |
| 28/01/202621:00 | Pafos | 4 - 1 | Slavia Praga |
| 28/01/202621:00 | Arsenal | 3 - 2 | Kairat Almaty |
| 28/01/202621:00 | Eintracht Francoforte | 0 - 2 | Tottenham |
